Bioactive Small Molecules
Selleck Chemical LLC GSK1016790A
GSK1016790A (GSK101) is a novel potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells
Cayman Chemical 5-APDIhydrochlorIde 5mg
An indane with an amphetamine-like aminopropane group; inhibits the uptake of serotonin, dopamine, and norepinephrine by crude synaptosomes (IC50 = 82, 1,847, and 849 nM, respectively)
Medchemexpress LLC AQX-016A 25mg | 849669-54-1 | 25 MG
AQX-016A is an orally active SHIP1 agonist research compound intended for laboratory use. It activates recombinant SHIP1 in vitro, modulates PI3K signaling, and is used as a chemical tool for inflammation and cell signaling studies. Provided as a solid with defined solubility and storage recommendations.
- High purity (≈99.5%) suitable for biochemical assays.
- Small-molecule SHIP1 agonist for modulation of PI3K pathway.
- Soluble in DMSO and ethanol with ultrasonic/warming recommended.
- Stable as powder at -20°C for long-term storage.
- Packaged as 25 MG for laboratory testing.
Medchemexpress LLC HY-P1037 1mg Medchemexpress, Motilin (26-47), human, porcine CAS:52906-92-0 Purity:>98%
Medchemexpress, HY-P1037 1mg Motilin (26-47), human, porcine CAS:52906-92-0 Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with K i and EC 50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 50 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC featuring a 2-oxoethyl linker. It functions by inducing Bcr-Abl degradation through a ubiquitinproteasom-dependent mechanism. This compound has demonstrated antiproliferative activity against K562 cells and shows promise for cancer research.
- PROTAC with a 2-oxoethyl linker.
- Induces Bcr-Abl degradation in a ubiquitinproteasom-dependent manner.
- Exhibits antiproliferative activity against K562 cells.
- Potential to study cancer.
Medchemexpress LLC LNP Lipid-3 | 2648693-32-5 | C₅₀H₉₅N₃O₄ | 5 MG
LNP Lipid-3 is an ionizable lipid with high purity, primarily used to synthesize lipid nanoparticles. It finds application in various drug delivery research endeavors.
- Ionizable lipid
- Used to synthesize lipid nanoparticles
- Applied in drug delivery research
- High purity (99.91%)
- Molecular weight of 802.31
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC 7-O-(amino-PEG4)-paclitaxel | 00-00-0 | 99.8% | 1101.19 g·mol⁻¹ | C58H72N2O19 | 5 MG
7-O-(Amino-PEG4)-paclitaxel is a PEG-based drug-linker conjugate that incorporates a paclitaxel moiety with a terminal amino group. It is intended for research use in the synthesis of antibody-drug conjugates (ADCs) and as a PROTAC linker, providing a convenient reactive handle for downstream coupling.
- Contains a paclitaxel moiety with a terminal primary amine.
- Amino group reactive with carboxylic acids, activated NHS esters, and carbonyls.
- Suitable for ADC synthesis and PROTAC construction.
- High molecular weight suitable for linker applications (approx. 1101.19 g·mol⁻¹).
- Provided in small research pack sizes with reported purity up to 99.8%.
- Store powder at -20°C; store in solvent at -80°C for long-term stability.
Medchemexpress LLC Myo-inositol trispyrophosphate hexa-triethylamine | 851086-77-6 | 98.0% | 1213.13 | C6H12O21P6 · 6C6H15N | 5 MG
myo-Inositol trispyrophosphate hexa-triethylamine is the hexa-triethylamine salt form of myo-inositol trispyrophosphate (ITPP). Supplied as a research-grade reagent (≥98.0% purity), it is used in biochemical and pharmacological studies, including investigations of oxygen delivery, tumor metabolism, and cardiovascular research. Available in small milligram pack sizes for in vitro and in vivo experiments.
- High purity (≥98.0%) suitable for research use.
- Supplied as a hexa-triethylamine salt to aid solubility and handling.
- Used in studies of oxygen delivery, tumor metabolism, and cardiovascular biology.
- Available in small milligram quantities for in vitro and in vivo applications.
- Characterized by molecular weight 1213.13 and CAS 851086-77-6.
eMolecules 224177-60-0 | SIRAMESINE (LU-28-179) | AstaTech | MFCD28144522 | 491.050 | C30H32ClFN2O | 95.000 | Cl.Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 | 0.1g | 282978653
SIRAMESINE (LU-28-179) | AstaTech | 224177-60-0 | MFCD28144522 | 491.050 | C30H32ClFN2O | 95.000 | Cl.Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 | 0.1g | 282978653
Medchemexpress LLC NRX-0492 | 2416130-57-7 | C43H51N11O6 | 100 MG
NRX-0492 is an orally active PROTAC-class BTK degrader that catalyzes BTK ubiquitination and proteasome degradation. It inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion, demonstrating antitumor effects against chronic lymphocytic leukemia.
- Catalyzes BTK ubiquitination and proteasome degradation
- Inhibits B cell receptor (BCR) mediated signaling
- Inhibits transcription programs and chemokine secretion
- Demonstrates antitumor effects against chronic lymphocytic leukemia
- Shows high-affinity binding to wild-type and C481S/T474I mutant BTK
- Induces BTK degradation in CLL cells from blood and spleen in vivo
- Reduces proportion of Ki67+/CD69+ cells in vivo
- Decreases splenic tumor burden in CLL patient-derived xenografts
Medchemexpress LLC Clofencet 1g | 129025-54-3 | 278.69 g/mol | C13H11ClN2O3 | 1 G
Clofencet is a small-molecule research chemical used as a wheat hybridizing agent. It is supplied as a high-purity solid for laboratory and agricultural research and is accompanied by safety documentation for handling and storage.
- High purity: 98.62% (reported).
- Molecular weight: 278.69 g/mol.
- Chemical formula: C13H11ClN2O3.
- Available in small packaging sizes suitable for lab use, including 1 G.
- English safety data sheet provided for safe handling and storage.
Medchemexpress LLC 6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one | 1614262-83-7 | 99.8% | 25MG
6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one | 1614262-83-7 | 99.8% | 25MG